Patagonian Museum of Natural Sciences, Natural sciences museum in General Roca, Argentina.

The Patagonian Museum of Natural Sciences Juan Carlos Salgado occupies the former Banco Provincia building in General Roca, designed by Carlos Libedinsky and Mario Linder, which won a 1971 competition and was completed in 1978. Its more than 1,800 m² make it the largest museum in Río Negro province. Four exhibition rooms begin with paleontology, geology and mineralogy, and the biodiversity of northern Patagonia.

The museum was created by Río Negro provincial law 4077/06 in 2006, the first museum established by law in the province, and opened on 3 March 2008. It is run by the Fundación Patagónica de Ciencias Naturales, founded in 2002 by Juan Carlos Salgado, Hugo Alberto Chafrat, Jorge Nori, Héctor Piacentini and Armando Gentili. Its building, designed by Carlos Libedinsky and Mario Linder, was built in 1978 for the Banco Provincia and later ceded to the foundation.

The museum is run by the Fundación Patagónica de Ciencias Naturales, created in 2002 by General Roca residents Juan Carlos Salgado, Hugo Alberto Chafrat, Jorge Nori, Héctor Piacentini and Armando Gentili to found a natural sciences museum. Its name honours Salgado. The foundation also publishes books such as Reptiles de Río Negro and produces the documentary series Gigantes del Sur, broadcast since 2015.

The museum occupies the former Banco Provincia building, designed by Carlos Libedinsky and Mario Linder, completed in 1978 and covering more than 1,800 m². It is administered by the Fundación Patagónica de Ciencias Naturales, which has held the building on loan since 2019 for another ten years. The exhibition halls begin with palaeontology, geology and mineralogy, followed by the biodiversity of northern Patagonia.

The museum's scientific collection was declared of scientific, technological and economic interest by Río Negro's innovation agency on 7 June 2021, recognising its curation and research work. Its specimens are catalogued in sections such as vertebrate palaeontology (MPCN-Pv), invertebrate palaeontology (MPCN-Pi) and palaeoichnology (MPCN-Pic).