Umtamvuna Nature Reserve, Protected area in KwaZulu-Natal, South Africa.

Umtamvuna Nature Reserve covers 3,257 hectares on the KwaZulu-Natal side of the Mtamvuna River, from the edge of Port Edward about 19 km inland, with roughly 28 km of river frontage and the Bulolo tributary. Grassland plateaus drop into Coastal Scarp Forest in the gorge, where cliffs up to 240 m high were cut by the river into Natal Group Sandstone.

The reserve was established on 25 July 1971 and is managed by Ezemvelo KZN Wildlife. It covers 3,257 hectares on the KwaZulu-Natal side of the Mtamvuna River, which forms its southern boundary opposite the former Transkei. The nearest town is Port Edward, about 8 km northeast of the reserve.

The reserve is named after the Mtamvuna River, which forms its southern boundary and runs for about 28 km along the reserve. The rare plant Watsonia mtamvunae grows here, one of the species tied to the reserve's sandstone soils. The nearest town is Port Edward, about 8 km to the southwest.

The area has several marked walking trails with varying difficulty levels and lengths suitable for different fitness levels. There are also viewpoints and places for observing wildlife.

The cliffs were cut by the Mtamvuna River incising into Natal Group Sandstone, and many endemic plants grow on this rock and the soils derived from it. The rare Watsonia mtamvunae occurs in the reserve. A colony of Cape vultures is said to nest on cliff faces up to 240 m high.