Old Basilica of Guadalupe, Monterrey, Catholic basilica in Colonia Independencia, Monterrey, Mexico.

The Old Basilica of Guadalupe is a Roman Catholic church in the Colonia Independencia, just outside Monterrey's downtown. It is a smaller stone building standing barely 50 metres from the newer basilica that replaced it as the city's Guadalupe sanctuary. Inside, an oil-on-canvas painting of the Virgin of Guadalupe hangs over the altar, and a 1931 four-manual Wurlitzer organ is kept in the church.

Bishop Francisco de Paula Verea y González, devoted to the Virgin of Tepeyac, ordered a small ashlar church built here in 1867, with an oil painting of the Virgin of Guadalupe on the altar and Mass celebrated outdoors in front of it. In 1895 Bishop Santiago de los Santos Garza Zambrano replaced it with the larger stone structure that stands today. In the 1960s the sanctuary became a parish church for Colonia Independencia, and the present basilica complex took over as the Guadalupe center in the later 20th century.

The basilica holds central importance in religious observances, particularly during the annual December 12 celebration honoring the Virgin of Guadalupe. Visitors experience the deep devotion that people show at this sacred site.

The site is easily accessible, as public transportation was expanded in 1905 to accommodate increasing visitor numbers. Today visitors will find good transit connections, especially during December celebrations.

A four-manual Wurlitzer organ was installed in 1931 and remains a distinguishing feature of this religious landmark. The organ produces rich, resonant tones that fill the space during services.