Holly Bluff Site, Archaeological site in Yazoo County, Mississippi, United States.

Holly Bluff Site is an archaeological site in Yazoo County, Mississippi, with twenty-five recognized mounds. Mound A, near the center, is 17 m high and covers nearly 0.8 hectares. Seven mounds line the bank of George Lake, six lie within the enclosing embankment, and twelve surround two plazas east and west of Mound A.

Excavations at the site began in 1908 when Clarence Bloomfield Moore discovered artifacts and two disturbed burials after obtaining permission from Judge William Andrew Henry. The findings show that people occupied and used this location across multiple centuries.

The location shows evidence of multiple periods of Native American occupation, from the Jaketown Phase through the Baytown period, revealing how people's practices and ways of living changed over many generations. The arrangement of the mounds and how they were used provide clues to the ceremonies and daily activities of these communities.

The site is located in a remote area of Yazoo County and typically requires contacting administrators before visiting. Reaching the grounds involves traveling on rural roads, so it is wise to check conditions beforehand.

Mound A features an unusual layout with two separate plazas positioned on its eastern and western sides, differing from how ceremonial centers were typically built. This two-plaza arrangement gives archaeologists clues about the complex ways the space was used for different gatherings.