Fulton Lock, lock and dam on the Tennessee-Tombigbee Waterway in Fulton, Mississippi, United States

Fulton Lock is a lock and dam on the Tennessee-Tombigbee Waterway at mile 391, measured from the Cochrane–Africatown USA Bridge in Mobile, Alabama. It sits in Fulton, Mississippi, where the waterway forms the city's western boundary, and U.S. Route 78 crosses the water on an overpass just south of the structure. Its dam holds back a 1,643-acre lake.

Fulton Lock, originally designated Lock C, was built as part of the Tennessee-Tombigbee Waterway at a cost of $28.3 million. Its dam created a 1,643-acre lake north of the structure, on which two recreation areas and the Whitten Historical Center now stand. The lock sits at mile 391 of the waterway, the distance measured from the Cochrane-Africatown USA Bridge on U.S. Route 90 in Mobile, Alabama.

The lock is named for Fulton, the Mississippi city whose western boundary the waterway forms. North of the dam the impoundment covers 1,643 acres and holds two recreation areas plus the Whitten Historical Center, so the pool is used for boating and fishing as well as navigation.

The lock is visible from U.S. Route 78, which crosses the waterway just south of the structure. Visitors can access nearby recreational areas and the Whitten Historical Center to learn about local history and the waterway's role in the region.

Fulton Lock's standby radio channel is 16, but its own working channel is 74, so tow captains switch frequencies before entering. The lock was built for $28.3 million and its dam created a 1,643-acre lake north of the structure, where the Whitten Historical Center and two recreation areas sit.