Dr. John R. Drish House, Antebellum plantation mansion in Tuscaloosa, Alabama.

The Dr. John R. Drish House is a large stuccoed brick mansion in Tuscaloosa, Alabama, built in 1837 at the center of a 450-acre plantation. Its two-story main block has a three-story square tower with a hip roof and brackets at the left, and a two-story portico with four smooth columns on the right wing. Tall dark windows in rows and white trim, columns and window surrounds complete the facade.

The stuccoed brick mansion was built in 1837 for Dr. John R. Drish, a Virginia native who settled in Tuscaloosa in 1822, on a 450-acre plantation at the edge of town; enslaved artisans did much of the plasterwork. State architect William Nichols is usually credited with the Greek Revival design. Before the Civil War the house was remodeled in the Italianate style, adding a three-story brick tower, Ionic columns and bracketed eaves. Drish died in 1867, reportedly from a fall down a stairway.

The residence displays how wealthy Southern planters expressed their status through architectural choices, blending Greek Revival and Italianate elements that were fashionable among the planter elite. These design decisions reflected the social hierarchy and aesthetic values of antebellum Alabama society.

The house stands at 2300 17th Street on Tuscaloosa's south side, near the intersection with 23rd Avenue. It opened as an event venue in May 2016 after exterior and interior renovations, so it is generally seen during booked gatherings rather than by walk-in tour. The 2009 demolition of the church additions left the mansion standing alone on its lot.

The house appears in Walker Evans's photograph taken in 1935 or 1936, when it served as a parts warehouse for Charles Turner's Tuscaloosa Wrecking Company; the image is held at the Metropolitan Museum of Art. Since the early 20th century, people have reported seeing the third-story tower ablaze when no fire was present, a tale retold in "Death Lights in the Tower" in 13 Alabama Ghosts and Jeffrey.