Cahaba River National Wildlife Refuge, National Wildlife Refuge in central Alabama, United States.

Cahaba River National Wildlife Refuge covers 3,689.63 acres in Bibb County, Alabama, from just north of the Little Cahaba and Cahaba river confluence to Piper Bridge, about five miles east of West Blocton. About 3.5 miles of the Cahaba River flow through it, at the southwestern end of the Appalachian chain. The refuge is unstaffed and administered from Anniston.

The refuge was established in 2002 by the United States Fish and Wildlife Service to protect the Cahaba River ecosystem and its surroundings. This creation reflected efforts to preserve the region's natural resources for the future.

The Cahaba lily, called Hymenocallis coronaria in botanical Latin, is known in Alabama simply as the Cahaba lily, and its abundance along this stretch of river was one reason the refuge was created. The refuge is unstaffed and administered from the Mountain Longleaf National Wildlife Refuge in Anniston, so visitors arrange their own river trips.

Visitors can access the refuge through multiple entry points to pursue hiking, wildlife watching, photography, and fishing in designated areas. Wearing comfortable walking shoes and dressing for wet conditions is helpful, since the terrain includes swampy sections.

The refuge holds the largest known population of Cahaba lilies, rare aquatic plants that grow only in the rocky sections of the river. These distinctive flowers bloom during spring and are a signature feature of the waterway.