Greek Orthodox Church of the Holy Trinity, Byzantine Revival church in Charleston, United States

The Greek Orthodox Church of the Holy Trinity is a Byzantine Revival church in Charleston with a prominent central dome. The dome was constructed using decorative tile work, and the interior features traditional religious icons displayed throughout.

The first Greek Orthodox church in South Carolina was built in 1911 at Fishburne and St. Phillip Streets. Construction of the present church at 28 Race Street began in 1950 and was completed in 1953. The building was listed on the National Register of Historic Places in 2004.

The religious icons inside were created by an artist from Athens and display traditional Byzantine painting methods. These artworks serve as a bridge between the congregation and the spiritual dimension central to Orthodox worship.

The church stands at 28 Race Street in downtown Charleston, a short walk from the City Market area. Visitors are welcome during regular services; the interior is in use for worship, so dress and conduct should suit an active parish.

The central dome was designed and built by the Guastavino Tile Company of Woburn, Massachusetts, a firm from New England rather than Charleston. The parish's longest-serving pastor, Rev. Nicholas Trivelas, arrived in 1947 and led it for nearly five decades.