San Pablo Lytton Casino, Gaming establishment in San Pablo, California.

San Pablo Lytton Casino is a gaming facility in San Pablo, California, with over 1,500 slot machines offering a range of denominations. The venue features a large gaming floor designed to accommodate many players at once.

The site originally operated as a trailer park and bowling alley before becoming a card club in 1994. A decade later, the introduction of video gaming in 2002 marked its evolution into the current casino operation.

The casino is run by the Lytton Band of Pomo Indians, a tribe of about 350 people. Its revenues supply more than half of San Pablo's municipal funding, and the city receives a 7% share. In 2018 the tribe gave $1 million to a fund for victims of the Camp Fire.

The casino sits next to the site of the former Doctors Medical Center, which the tribe bought in 2017 and later replaced with parking lots. In 2019 the tribe purchased the hospital site for $13.5 million and razed it to add 1,000 parking spaces, easing parking in surrounding neighborhoods. Visitors must be 21 or older to enter the gaming floor.

In 2019 the operation purchased an adjacent former hospital property to expand its facilities. This acquisition allowed the creation of 1,000 additional parking spaces at the new location.