Division Street Bridge, Road bridge in Downtown Spokane, Washington, United States.

Division Street Bridge is a concrete bridge that crosses the Spokane River in downtown Spokane. The structure carries six travel lanes and has sidewalks running along both sides.

The first wooden span was built in 1888, carrying Division Street over the Spokane River. In 1892 the San Francisco Bridge Company replaced it with a steel bridge designed by Hugh L. Cooper, damaged in the 1894 flood and repaired. On 18 December 1915 its northern section gave way beneath two trolley cars, killing five and injuring twelve; a concrete bridge followed in 1917.

The current span, opened in 1992, is officially the Senator Sam C. Guess Memorial Bridge. It carries Division Street, U.S. 2 and U.S. 395 over the Spokane River, about half a mile upstream of Spokane Falls. Two access points link the bridge to the Spokane River Centennial Trail running beneath it.

Access to the Spokane River Centennial Trail is available beneath the bridge through two connection points for pedestrians and cyclists. These routes are easy to reach on foot or by bike.

During the 1894 flood, a displaced railroad bridge was swept by floodwaters and crashed into the Division Street structure. This impact damaged it and contributed to the later failure of that steel span.