Saint Sophia Church, Drama, Eastern Orthodox church building in Drama, Greece.

Saint Sophia Church in Drama is an Orthodox religious building with Byzantine architectural features, including a central dome and stone walls that define its structure. The interior contains areas for prayer and worship designed according to Orthodox Christian traditions.

Hagia Sophia was built in the 10th century on Drama's highest point, together with the city walls, using the same stones; it probably stood on the site of an earlier Christian basilica and was likely dedicated to the Virgin Mary. According to Metropolitan Agathangelos it became a mosque in 1430, though others date the conversion to the reign of Murad I; under Ottoman rule it was called Bey Mosque. It returned to Christian worship after Drama joined Greece in the Balkan Wars, and in 1922 refugees from Anatolia and Eastern Thrace dedicated it to the Holy Wisdom of God.

The church was dedicated to the Holy Wisdom of God in 1922 by Greek refugees from Anatolia and Eastern Thrace resettled in Drama. Under Ottoman rule it was called Bey Mosque. A 1917 mural of the Second Coming covers the narthex, and the original Dormition of the Mother of God fresco, plastered over in Ottoman times, survives in the sanctuary.

The church stands at Drama's highest point, and later embankments raised the ground around it, so the floor now sits below street level. The bell tower is the former Ottoman minaret, and the western part of the building served as a mosque. A Ministry of Culture restoration is removing these later additions and excavating the western Byzantine section, so parts of the exterior may be closed off.

The church sank into the ground over centuries as later embankments raised the soil level, which reinforced its stability and may explain why it survived the 1829 earthquake that levelled Drama. Its bell tower was formerly the minaret of the Bey Mosque.