Sant'Antonio, Baroque church in Marina district, Cagliari, Italy.

Sant'Antonio is a baroque church in Cagliari's Marina district, built on an octagonal plan slightly elongated toward the presbytery. Its large dome, topped by a lantern, covers the entire structure, and the facade portal is framed by two large splayed pilasters with composite capitals. The interior has green plaster walls with gilded Corinthian capitals and a deep presbytery housing a polychrome marble altar.

A hospital and convent stood here from 1342, run by Augustinian friars until 1638, when the Hospitallers of St. John of God took over. In 1674 that order decided to replace the 13th-century hospital chapel with a new church, consecrated in 1723 by auxiliary bishop Antonio Sellent, as the plaque in the atrium records. In 1850 the Hospitallers moved to the new hospital designed by Gaetano Cima, and the church passed to the Arciconfraternita della Madonna d'Itria.

The church is a rectory of the parish of Santa Eulalia and belongs to the Arciconfraternita della Madonna d'Itria, founded in 1607. On 17 January, the feast of the titular saint, domestic animals are blessed in the nearby Piazza San Sepolcro, since Saint Anthony Abbot is their protector. The confraternity's altarpiece of the Madonna d'Itria, second chapel on the left, came from the oratory of Sant'Agostino.

The church faces Via Giuseppe Manno in the Marina district, a short walk from Piazza San Sepolcro, where the 17 January animal blessing is held. It is an active parish church, so visits fit around services; the atrium plaque with the 1723 consecration date is the first thing to look for on entering.

The church stands on the site of Cagliari's old city hospital and convent, built in 1342 or perhaps as early as the 12th century. Augustinian friars ran it until 1638, when it passed to the Hospitallers of St. John of God, who replaced the 13th-century chapel with the present church in 1674.