Iglesia de la Preciosa Sangre, Santiago de Chile, Roman Catholic church in Plaza Brasil district, Santiago, Chile.

Iglesia de la Preciosa Sangre is a church with a Latin cross floor plan and a central nave adorned with stations of the cross along its interior walls. The building stands at Compania 2226 on the northwestern side of Plaza Brasil.

Construction of the church, convent and adjoining buildings began in 1873 under the Italian architect Eusebio Celli; after his death Ignacio Cremonesi completed the work, and the church was inaugurated in 1906. The Congregation of the Precious Blood, founded by Mother Magdalena Guerrero Larraín, had its constitutions approved on 2 October 1887. Her remains lie beside the main altar.

The Congregation of the Precious Blood, whose constitutions were approved on 2 October 1887, ran schools and health care from here, including the Colegio de la Preciosa Sangre and the Clínica Psiquiátrica Santa Cecilia. The founder, Mother Magdalena Guerrero Larraín, lies buried beside the main altar, and Sunday Mass still draws faithful from neighbouring parishes.

The church stands at Compañía de Jesús 2226, on the northwestern side of Plaza Brasil in Santiago's historic centre, a short walk from the Cumming and Plaza Brasil bus stops. It opens for Sunday Mass, which also draws faithful from neighbouring parishes. In April 2025 the organisation Principios Patrimonio carried out a visual and tactile survey of the north and east façades as part of a preventive maintenance plan.

The church originally housed a Cavaille-Coll organ, one of the rare surviving examples of this famous French organ builder in South America. This instrument was a precious part of the church's heritage and reflects Santiago's international connections in the early 1900s.