Iglesia de Santo Domingo, La Serena, Colonial stone church in La Serena, Chile.

Iglesia de Santo Domingo is a Mannerist stone church on Gregorio Cordovez Street in La Serena. Its single nave measures 45 metres long and 9 metres wide. The limestone facade has a cedar-wood door framed by pilasters and a broken pediment, with a niche above holding a statue of Our Lady of the Rosary. The eclectic bell tower was added in the second half of the 19th century.

The Dominicans built the first church of ashlar and wood here between 1673 and 1675. On 15 September 1686 the English pirate Edward Davis, with some 200 buccaneers, failed to take La Serena and barricaded himself in the church and cloister; the militia drove him out, but he burned part of the cloister. Rebuilt with limestone from Alto Peñuelas and reopened around 1775 through the efforts of Fraile Domingo Meneces, it was damaged by the 1801 earthquake and remodelled in 1850.

The church is dedicated to Saint Dominic of Guzmán, and its main altar holds an image of Our Lady of the Rosary, the church's patroness; side altars carry statues of Saint Dominic and Francis of Assisi. A local legend tells that during the 18th-century rebuilding, a sea surge reaching the Santo Domingo gully withdrew after the Virgin's statue was carried out in procession. The temple is now administered by the Instituto Secular Voluntad Dei under a concession from the Dominicans.

The church stands at 235 Gregorio Cordovez Street, between Manuel Antonio Matta and Pedro Pablo Muñoz, in the historic quarter. The former cloister grounds were sold and are now a private parking lot, so no convent buildings remain to visit. Look for the cedar door framed by pilasters and a broken pediment.

The cloister that once stood beside the church housed the region's first secondary school in 1821, second in Chile after Santiago's Instituto Nacional. In 1851, during the Siege of La Serena, it served as a cemetery where hundreds of bodies were buried; no trace of those remains survives. The cloister buildings are gone, and the land was sold for a private parking lot.