Mission San Carlos Borromeo, Colonial religious site in San Carlos, Argentina

Mission San Carlos Borromeo is a Jesuit mission site in San Carlos, Corrientes, Argentina, founded in 1631 by Pedro Molas. It lies at 27°44′35.70″S 55°54′01.70″W and preserves remains of the mission settlement established among the Guaraní during Spanish colonization.

The Jesuit missions were founded to evangelize the Guaraní people and teach them European skills and practices. They became centers of colonial influence across the region during the 17th and 18th centuries.

The mission was founded in 1631 by Pedro Molas, a Jesuit, in what is now San Carlos, Corrientes. Its name honours San Carlos Borromeo, the Counter-Reformation bishop of Milan, a dedication typical of the Jesuit Province of Paraguay. The site belongs to the network of missions the Society of Jesus ran among the Guaraní under Spanish colonial rule.

The site is best explored on foot, with ruins scattered across open ground throughout the property. Information panels are available at the location to help identify different areas, though a basic understanding of mission layouts in advance is helpful.

The mission was founded in 1631 by Pedro Molas, in what is now San Carlos, Corrientes province, Argentina. It was one of the establishments of the Society of Jesus in the Jesuit Province of Paraguay during Spanish colonization. The site lies at about 27°44′S 55°54′W, coordinates a visitor can use to locate the ruins.