La Santísima Trinidad del Paraná, Jesuit mission ruins in Trinidad, Paraguay.

La Santísima Trinidad del Paraná is the best-preserved and most extensive Guaraní reduction in Paraguay, set on a hill 28 km northwest of Encarnación. Around the Plaza Mayor stand the Iglesia Mayor, the largest temple of the Jesuit reductions, with its frieze of musician angels, and rows of Indian houses whose stone arcades face the square. Each house block measures 20 metres, separated by a street, with carved stone rosettes above the lintels. A square-based tower stands apart from the church.

Founded in 1706 as a Jesuit reduction, the settlement developed into one of the largest missions in the region until Spanish authorities expelled the Jesuit order from their colonies in 1768.

The architectural design merges European baroque forms with indigenous Guaraní craftsmanship through elaborate stone carvings and construction techniques that created a shared artistic tradition.

The ruins sit on a hill 28 km northwest of Encarnación, in Trinidad district, Itapúa, reached from Route VI. The site is under constant restoration and maintenance work, so some areas may be closed off. A Jesuit museum occupies the old sacristy, showing sculptures and a model of the mission, and a lithic museum is set up in the sacristy and in one of the galleries.

The frieze of the musician angels in the main church shows a row of angels playing the clavichord, pipe organ, trumpets, clarinets, flute and Paraguayan harp. Until musical scores were found in Moxos, Bolivia, it was the only evidence of music in the Jesuit missions.