Palacio de la Autonomía, History museum in Centro district, Mexico City, Mexico

The Palacio de la Autonomía is a late-19th-century eclectic building of white stone from Pachuca, on the corner of Licenciado Verdad and República de Guatemala. Its facade has a triangular pediment with relief and foliage, and part of its foundation rests on the wall that surrounded the sacred plaza of the Templo Mayor. It now houses the Museo de la Autonomía Universitaria.

The site belonged to lands Hernán Cortés distributed after the Conquest, was later reserved for Luis de Rivera, first representative of the Casa de Moneda, then formed part of the Santa Teresa la Antigua convent and became housing after the Reform Laws. Porfirio Díaz's government built the present stone building, ceded to the university in 1910, which housed the Escuela Normal de Maestros. In 1929 the documents granting UNAM autonomy from direct government control were signed here.

The museum keeps the Salón de la Odontología Mexicana, a hall devoted to the history of Mexican dentistry, alongside a temporary exhibition room and an archaeological display. It also houses the UNAM-FM university radio station and archives on the figures who led the 1929 autonomy struggle. Windows cut into the foundation let visitors look at remains of the old Santa Teresa la Antigua convent.

The museum entrance is on the corner of Licenciado Verdad and República de Guatemala, north of Santa Teresa la Antigua and east of the Templo Mayor. Inside, windows set into the foundation let visitors look down at remains of the old Santa Teresa convent. The building also houses the UNAM-FM radio station, so some rooms may be closed for broadcasts or temporary exhibitions.

The building's foundation rests on an ancient wall that once enclosed the sacred plaza of Templo Mayor. This location directly connects modern academic use with the pre-Hispanic history beneath the city.