Muleshoe National Wildlife Refuge, National wildlife refuge in Bailey County, Texas.

Muleshoe National Wildlife Refuge covers 6,440 acres of High Plains shortgrass prairie about 20 miles south of Muleshoe on State Highway 214. Its core is a chain of intermittent salt lakes, some diked to hold water longer; Paul's Lake, east of the highway, is spring-fed and stays wet when the others dry. A small field of white gypsum dunes lies northeast of White Lake.

President Franklin D. Roosevelt created the Muleshoe Migratory Waterfowl Refuge by executive order in 1935, making it the oldest national wildlife refuge in Texas. A 1940 proclamation changed its name to Muleshoe National Wildlife Refuge. The National Park Service designated it a national natural landmark in 1980.

The refuge uses traditional land management practices that keep the grasslands healthy and productive. Visitors can observe how these techniques shape the landscape and support the wildlife that depends on these habitats.

Visitors drive south from Muleshoe on Highway 214 and then west on Caliche Road to reach the refuge. Bringing binoculars is helpful for spotting birds and wildlife, and allowing plenty of time makes for better viewing opportunities.

Northeast of White Lake, white gypsum dunes appear across the landscape, resembling a smaller version of White Sands. This rare feature adds visual interest to the site and stands out against the flatter grassland surroundings.