El Camino Real de los Tejas National Historic Trail, National historic trail from Texas to Louisiana, United States.

El Camino Real de los Tejas is a historic corridor about 2,500 miles (4,000 km) long, running from Mexico City through Saltillo, Monterrey, Laredo, San Antonio and Nacogdoches to Natchitoches, Louisiana. Modern Texas 21 and Louisiana 6 roughly follow the route. A circular mosaic sign beside a paved path shows "EL CAMINO REAL" above wave patterns and dark stones.

Spanish governor Alonso de León forged the first connections through this wilderness between 1686 and 1690 to reach missions in East Texas. The pathway expanded over centuries, eventually linking Mexican provinces with French trading posts in Louisiana.

The route follows paths used by indigenous communities centuries before Spanish arrival. These connections later enabled exchange between missions, ranches, and early Texan settlements, whose descendants still live throughout the region today.

Visitors can follow the alignment along Texas Highway 21 and Louisiana Highway 6, where interpretive centers provide background information. Most segments remain accessible year-round, though some rural stretches may become difficult to navigate during rainy weather.

The Daughters of the American Revolution placed granite milestones every 5 miles (8 km) along the route after the Texas Legislature funded a 1915 survey by V. N. Zivley. Some markers now stand in private yards or along abandoned country roads.