Hobe Sound National Wildlife Refuge, National wildlife refuge in Martin County, Florida, United States

The Nathaniel P. Reed Hobe Sound National Wildlife Refuge covers 1,035 acres, split by the Indian River Lagoon into two tracts. The 735-acre Jupiter Island tract holds beach and coastal hammock; the 300-acre mainland tract holds sand pine scrub. The 173-acre Reed Wilderness Seashore Sanctuary, a National Natural Landmark since November 1967, lies within it.

The refuge was established on September 30, 1969, to protect loggerhead and green sea turtles. In November 1967, before the refuge itself existed, the 173-acre Reed Wilderness Seashore Sanctuary within it had already been designated a National Natural Landmark. In 2019 the refuge was officially renamed the Nathaniel P. Reed Hobe Sound National Wildlife Refuge.

The Hobe Sound Nature Center is a private non-profit founded in 1973 by the Jupiter Island Garden Club, which still gives it major support. Working with the U.S. Fish and Wildlife Service, it runs environmental education and awareness programs about the refuge. Its indoor displays show several native species.

The refuge is split by the Indian River Lagoon into two tracts: the 735-acre Jupiter Island beach tract and the 300-acre sand pine scrub tract on the mainland. Trails pass through sand pine scrub, coastal hammock and protected beach, with an indoor display of native species. The Hobe Sound Nature Center, founded in 1973, runs the education programs.

The refuge protects part of the rare sand pine scrub forest, a habitat found only in Florida and one other area in the Southeast. This forest type is uncommon and valuable for specialized plants and animals that grow nowhere else.