Saint Spiridon Orthodox Cathedral of Seattle, Orthodox cathedral in Cascade neighborhood, Seattle, United States.

Saint Spiridon Orthodox Cathedral is a brick church in Seattle's Cascade neighborhood, built in 1941 to a design by architect Ivan Palmaw from 1931. Its patron is Saint Spyridon, and the congregation belongs to the Orthodox Church in America.

The parish was founded in 1895, its congregation rooted in an 18th-century Orthodox mission to Alaska. Architect Ivan Palmaw designed the present church in 1931, and the building was completed in 1941. Its patron is Saint Spyridon, and it belongs to the Orthodox Church in America.

The parish traces its roots to an 18th-century Orthodox mission to Alaska, and its patron is Saint Spyridon, a 4th-century bishop of Trimythous honoured on 12 December. The congregation has been multi-ethnic since its founding in 1895, drawing on that missionary heritage.

The cathedral stands at 400 Yale Avenue North, at the corner of Yale Avenue North and Harrison Street in the Cascade neighbourhood, a short walk from the South Lake Union streetcar line. Services follow the Orthodox calendar, so check the parish schedule before visiting; the building is otherwise closed to casual visitors.

The parish was founded in 1895, and its congregation traces its roots to an 18th-century Orthodox mission to Alaska. The present church was designed by architect Ivan Palmaw in 1931 and completed in 1941. Its patron is Saint Spyridon, a 4th-century bishop of Trimythous on Cyprus, venerated in the Orthodox Church.