Henry Piper House, Historic residence on the National Register in Virginia City, Nevada.

The Henry Piper House is a one-and-a-half-story house on B Street in Virginia City, Nevada, now run as the B Street House Bed and Breakfast. It was completed by December 1875, after the Great Fire, and holds six guest rooms, each with a private bathroom, furnished with antiques. It is the only bed and breakfast in Virginia City housed in a building individually listed on the National Register of Historic Places.

The house was built after the Great Fire of 1875, which destroyed much of Virginia City, and was completed by December of that year. Henry Piper had moved to Virginia City in 1861 with his older brother John; the two ran Piper's Opera House and the Piper's Corner Saloon. The house was renovated into a bed and breakfast between 2004 and 2007 and listed on the National Register of Historic Places in 2011.

Henry Piper arrived in Virginia City in 1861 with his older brother John; both held local political offices and jointly ran Piper's Opera House and the Piper's Corner Saloon at B and Union Streets. Henry served one term in the Nevada Assembly, then worked as a "box herder" at the opera house, managing the often drunk demimonde women and young miners in the audience.

Listed on the National Register of Historic Places under reference number 11000254, the house now operates as a bed and breakfast offering visitors accommodations in a historic setting.

The house received a historic preservation award from the state of Nevada in 2008, recognizing its successful restoration and continued operation as a hospitality establishment.