Knights of Pythias Building, Fraternal organization building in Virginia City, Nevada.

The Knights of Pythias Building is a two-storey lodge hall in Virginia City, Nevada, built in 1876 of cast iron and stuccoed brick. It is one of the few unaltered false-fronted buildings left in the town, with the lodge hall on the upper floor and a rented ground floor.

Nevada Lodge No. 1 of the Knights of Pythias, formed on March 23, 1873, built the hall in 1876 of cast iron and stuccoed brick. Lincoln Lodge No. 6 (1874) and Triumph Lodge No. 11 (1879) also met here. The building is a contributing property in the Virginia City Historic District, declared a National Historic Landmark in 1961 and added to the National Register of Historic Places in 1966.

Three Knights of Pythias lodges used the hall: Nevada Lodge No. 1, formed March 23, 1873, Lincoln Lodge No. 6 (1874) and Triumph Lodge No. 11 (1879). The lodge name and its initials are what visitors can look for on the false front, a reminder that fraternal orders organized much of Virginia City's social life.

The hall stands on C Street in Virginia City and is a contributing property of the Virginia City Historic District, a National Historic Landmark since 1961. It is a stop on foot tours of the old town. The upper floor was the lodge hall and the ground floor was rented out, shown as The Armory on an 1880 map.

The building is one of the few unaltered false-fronted buildings left in Virginia City. Its upper floor held the lodge hall while the ground floor was rented out; an 1880 map records The Armory occupying that first floor.