Dominguez Canyon Wilderness, Wilderness area in Mesa, Delta and Montrose counties, Colorado, United States

Dominguez Canyon Wilderness is a 66,280-acre protected area southeast of Grand Junction in western Colorado, within Delta, Mesa and Montrose counties. It holds two major canyon systems draining the northeastern corner of the Uncompahgre Plateau, and forms part of the 209,610-acre Dominguez-Escalante National Conservation Area.

Congress established this protected wilderness in 2009, making it the largest undeveloped Bureau of Land Management territory of its kind in Colorado. This designation recognized the need to keep the landscape intact and free from roads.

The canyons hold rock art panels and other traces left by the Ute and earlier peoples who used the Uncompahgre Plateau. The Dominguez-Escalante National Conservation Area is named for two 18th-century Spanish Franciscan friars, Francisco Atanasio Domínguez and Silvestre Vélez de Escalante, who crossed this region in 1776.

Access is via dirt roads off U.S. Highway 50 southeast of Grand Junction; the wilderness has no maintained trails, so route-finding and map skills are needed. The two canyon systems drain the northeastern Uncompahgre Plateau, and the area lies within the Dominguez-Escalante National Conservation Area. Carry water, as desert conditions prevail.

The entire area remains completely free of roads and developed infrastructure, making it one of the largest unbroken stretches of wild landscape in the region. This isolation lets visitors fully escape from modern construction and engineering.