St. Mary's Orthodox Church, Kottayam, Orthodox church in Kottayam, India.

St. Mary's Orthodox Church, known as Kottayam Cheriapally, is a Malankara Orthodox Syrian church on the road from Kottayam to Kumarakom, built in 1579 in a mix of Kerala and Portuguese styles. Its portico roof rests on ten granite pillars, one carved with a lotus from a single stone, and its walls over a metre thick hold niches for hundreds of oil lamps. The baptismal basin is chiselled from one block of stone.

A first church, Valiyapally, was built in 1550; after the congregation split along ethnic lines, the dissidents built Cheriapally in 1579 on land granted tax-free by King Goda Varman Manikandan. Portuguese architect Antony and his team worked with craftsmen of the Thekkumkore kingdom. Before the Old Seminary opened in 1815, Cheriapally served as headquarters of the Malankara Metropolitans.

The interior walls display mural paintings showing scenes from Jesus Christ's life, created by foreign artists using natural organic dyes. These artworks communicate religious stories to visitors as they move through the space.

The church stands on the Kottayam–Kumarakom road, on the way to Kumarakom from Kottayam. Visitors can see the Holy Girdle of St. Mary displayed from 10 to 15 August each year during the 15-day fast commemorating the Assumption. The church is dedicated to Mother Mary.

In 1966, Ignatius Yacub III presented the building with the Holy Girdle of St Mary, making it the first Indian church to receive these relics. This treasure attracts pilgrims and religious visitors to this day.