Islamic Center of Southern California, Islamic prayer center in Wilshire Center, Los Angeles, United States.

The Islamic Center of Southern California is a mosque on Vermont Avenue in the Wilshire Center neighborhood of Los Angeles, built in a style that features domes, geometric ornaments, and arched openings. The building contains separate prayer spaces for men and women, along with classrooms and rooms used for community gatherings.

Founded in 1952 in a rented property on Fountain Avenue in East Hollywood, the center was then the only mosque in Greater Los Angeles. It moved to City Terrace in the early 1960s, then to Jefferson Park in 1968, where Juma prayer, Quran tafsir, a weekend school and formalized marriage services were established. In the late 1970s it relocated about 3 miles northeast to 434 Vermont Avenue, its home today.

Since 2001 the center has held an annual Open Mosque day, when non-Muslims can tour the building and ask questions about Islamic practice; it was started to improve relations with the surrounding non-Muslim community. The center also houses New Horizon School - Los Angeles, a preschool-to-fifth-grade program of about 105 students, separate from its Sunday school.

The mosque sits in Wilshire Center, a neighborhood well served by public transit, and welcomes visitors at set times outside of prayer hours. Anyone entering should wear modest, covering clothing, and women are asked to bring a head covering.

For many years, this was the only mosque in one of the largest cities in the country, which meant Muslims traveled from across the wider Los Angeles region to gather here. That early role as the sole fixed meeting point shaped the congregation into a community with ties that go well beyond the immediate neighborhood.