South Serrano Avenue Historic District, Historic residential district in Mid-City, Los Angeles, United States.

The South Serrano Avenue Historic District covers the 400 block of South Serrano Avenue in the Mid City section of Los Angeles. The block holds 17 contributing houses built between 1912 and 1921, one non-contributing residence and two vacant lots. Frank M. Tyler designed several of the houses, including the William & Mary Glascock House at 451 and the Jose & Concepcion A. de Samaniego House at 420.

The houses were built during a period of rapid residential growth in Los Angeles during the 1910s. The district was added to the National Register of Historic Places in 1988, recognizing its importance as a well-preserved example of the city's early residential culture.

Architect Frank M. Tyler designed three of the houses: the William & Mary Glascock House at 451 S. Serrano Avenue, the Jose & Concepcion A. de Samaniego House at 420, and the Ellen and John Bolieu House at 414. Harry Hayden Whiteley, who worked in Tyler's office from 1907 to 1910, also designed houses on the block, and Henry J. Knauer designed the one at 403 S. Serrano Avenue.

The district lies in an urban area with limited parking, so visitors should arrive early or use nearby parking options. Since these are private homes, visitors must explore the neighborhood from public streets and respect the privacy of residents.

The district is the only intact block of single-family houses in a Mid City area dominated by large apartment buildings. Its 17 contributing houses were all built between 1912 and 1921, and the block was listed on the National Register of Historic Places in 1988.