Great Fish River Nature Reserve, Protected area in Eastern Cape, South Africa.

The Great Fish River Nature Reserve covers 45,000 hectares between 95 and 561 metres above sea level, where sharp cliffs drop into river valleys and broken ridges separate basins. Most of the ground is Great Fish subtropical thicket, and the Great Fish and Keiskamma rivers flow through the reserve.

Three separate reserves merged in 1994 to form the unified conservation area that exists today. This consolidation allowed for more effective protection of the river valley and its surrounding ecosystems.

The reserve's name comes from the Great Fish River, which, with the Keiskamma River, flows through its 45,000 hectares. The Great Fish River runs through the reserve and is one of the features that links the three former reserves, Andries Vosloo Kudu Reserve, Double Drift Nature Reserve and Sam Knott Nature Reserve, now joined by a circular route. The rivers also support the reserve's fish life: 24 fish species have been recorded in the reserve and its surroundings, among them two introduced species, the sharptooth catfish (Clarias gariepinus) and the largemouth bass (Micropterus salmoides).

Access is provided through marked pathways and routes that can be explored on foot or during guided drives. Plan your visit with awareness of weather conditions and road access, as the remote location requires preparation.

The elevation shift of nearly 500 meters creates conditions that support more than 200 bird species and stable populations of black rhinoceros. This combination of terrain and wildlife makes the reserve a crucial refuge for threatened animals.