Harlem Plantation House, Historic plantation residence on Louisiana Highway 39 near Pointe à la Hache, United States.

Harlem Plantation House is a raised Creole-American plantation house on Louisiana Highway 39 between Davant and Phoenix, on the east bank of the Mississippi River about 5 miles upriver from Pointe à la Hache. It was built around 1840 and substantially renovated around 1910.

The house was built around 1840 with French Colonial design characteristics of that era. Major renovations took place in 1910, and it has been listed on the National Register of Historic Places since 1982.

The house stands on the east bank of the Mississippi between Davant and Phoenix, a location that tied it to river traffic and the sugar and citrus economy of Plaquemines Parish. Its raised Creole-American form, with living quarters lifted above the ground, is the region's response to the river's floods, a threat that returned when levees were overtopped during Hurricane Katrina in 2005.

The house stands on Louisiana Highway 39 between Davant and Phoenix, on the east bank of the Mississippi about 5 miles (8 km) upriver from Pointe à la Hache. It is a private residence, so it is seen from the road; the river side faces the levee.

The walls contain original bousillage, a traditional building material made from mud, sand, Spanish moss, and animal hair used in early Louisiana construction. This material demonstrates how people in the region built with the resources they had on hand.