San Felasco Hammock Preserve State Park, Natural landmark and state park in Alachua County, Florida.

San Felasco Hammock Preserve State Park is a natural preserve and state park in Florida spanning thousands of acres of hardwood forests, swamps, and upland areas. The landscape supports populations of white-tailed deer, bobcats, and wild turkeys living within their native habitats.

The park holds 56 archaeological sites spanning the Paleo-Indian period, 10,000 to 12,000 years ago, through the 20th century. It includes the Spanish-era Mission San Francisco de Potano, listed on the U.S. National Register of Historic Places. The Battle of San Felasco Hammock, part of the Second Seminole War, was fought here in 1836, though its site remains unidentified.

The park maintains 56 archaeological sites representing different periods from Paleo-Indian settlements through 20th-century agricultural developments.

The park lies northwest of Gainesville on CR 232 (Millhopper Road), just south of Alachua, and holds 65 mi (105 km) of single-track bike, horse and nature trails. Gates are open from 8 a.m. until sundown every day of the year. A sign at the trailhead reads "San Felasco Hammock Preserve State Park — Bicycle and Horse Trails".

The park holds 56 archaeological sites, from Paleo-Indian camps 10,000 to 12,000 years old to 20th-century moonshine stills, a dairy farm, tung oil operations and a commune. The site of the Spanish-era Mission San Francisco de Potano, listed on the U.S. National Register of Historic Places, lies within the park.