Tabby Manse, National Register of Historic Places house in Beaufort, United States.

Tabby Manse is a historic residence from the late 1700s in Beaufort built using a distinctive material made from whole oyster shells mixed with limestone and finished with stucco. The exterior walls, approximately 2 feet (60 cm) thick, were constructed entirely from this oyster-based material that gives the house remarkable strength.

Thomas Fuller, a rice and cotton planter, built the house around 1786 as a wedding gift for Elizabeth Middleton, a descendant of Henry Woodward and cousin of Declaration signer Arthur Middleton. The couple raised twelve children here. After the Battle of Port Royal on November 7, 1861, Federal occupation displaced the family; in 1862 the Reverend Mansfield French occupied it, and in 1864 he bought it at a tax auction. In 1969 George Graham Trask and Constance Claire Bowen restored it and added a kitchen.

The name Tabby Manse comes from the oyster-shell concrete of its walls and from the guest house run here for almost a century by Almira Onthank and her nieces Emma Onthank and Alma and Clara Greenwood. Francis Griswold wrote A Sea Island Lady while staying here in the 1930s, using the interior as the heart of the house he called Marshlands.

Tabby Manse stands on a Beaufort street in the Beaufort Historic District, a National Historic Landmark district, so it can be viewed from the public sidewalk. The scored stucco that imitates stone blocks and the two-foot-thick tabby walls are best examined from outside. It remains a private residence, so the pine-panelled rooms are not open to visitors.

This building stands as one of very few surviving early American houses with exterior walls built entirely from tabby, a local building technique rarely found elsewhere in this region of South Carolina. This rare construction method makes it an important example of old Lowcountry building traditions.