Mulberry Plantation, Historic plantation in Kershaw County, United States

Mulberry Plantation, also known as the James and Mary Boykin Chesnut House, is a historic plantation at 559 Sumter Highway south of Camden, South Carolina. Its main house, built about 1820, is a 3+1⁄2-story Federal-period brick house on a high point about 0.25 miles east of the highway, with possible design input from architect Robert Mills. An early 20th-century wrought iron gate spelling "Mulberry" stands between brick piers across the road.

Archaeological research of platform mounds on the property documents human habitation back to about 1250 CE, and the site is believed to be Cofitachequi, the chiefdom visited by Hernando de Soto in the 16th century. James Chesnut established the plantation in the 1760s; it passed to his brother John and then to John's son, James Chesnut Sr. (1775–1866), under whom it grew to more than 12,000 acres.

Mary Boykin Chesnut lived here and kept journals that are now among the most read firsthand accounts of the American Civil War. Her writing captures daily life on the plantation from a Southern woman's point of view, and readers still return to her words today.

Comfortable footwear is a good idea because reaching all the buildings means walking the carriage lane and outdoor paths. The ground near the main house is fairly level, though the wider landscape gets more rolling as you move away from the central structures.

Archaeological research of platform mounds on the property traces human habitation here to about 1250 CE. The land is believed to be the site of Cofitachequi, the chiefdom the explorer Hernando de Soto visited in the 16th century, and it also holds a second archaeological site, the McDowell Site.