Palazzo del Seminario dei Chierici, Baroque palace at Piazza Duomo in Catania, Italy.

The Palazzo del Seminario dei Chierici is a Baroque palace on Piazza Duomo in Catania with a striking facade combining white Ispica stone inserts against dark volcanic plaster. The building features large windows decorated with ornamental pediments and spans multiple stories arranged with symmetrical openings.

After the 1693 earthquake, architect Alonzo di Benedetto rebuilt the structure, which then served as a seminary for priests until damage during World War II. The reconstruction was part of Catania's larger rebuilding effort in the Baroque style.

The building now houses the Diocesan Museum of Catania, displaying religious objects and artworks connected to the region's church history. Visitors can explore rooms filled with sacred items that show how spiritual life shaped the city over time.

The palace occupies the south side of Piazza Duomo, beside the Cathedral of Sant'Agata and facing the Palazzo degli Elefanti, with the Elephant Fountain between them. The square is pedestrian ground in the historic centre, so it is reached on foot; the building itself is a working municipal and museum site rather than a monument entered from the piazza.

A passage connects this palace to the Cathedral of Sant'Agata through the Uzeda Gate, incorporating parts of ancient walls from the time of Charles V. This connection reveals how different periods of the city's history are woven together.