Palazzo Caracciolo di Melissano, Baroque palace in San Potito district, Naples, Italy.

Palazzo Caracciolo di Melissano is an 18th-century palace on the San Potito hill in Naples, built ex novo by architect Luca Vecchione for Giovanni d'Afflitto, count of Trivento, in 1763. It has five levels, including a mezzanine and ground-floor shops, arranged around a small central courtyard. The windows have organic carvings with alternating triangular and curved pediments on the three upper noble floors, and the piperno portal is a round arch with Ionic pilasters and the Cito marble coat of arms.

Built during the 18th century, this palace displays architectural elements similar to other civil buildings designed by architect Luca Vecchione in Naples. Its design was influenced by earlier works, particularly the 17th-century Palazzo Terralavoro, whose formal features were adapted for this building.

The windows display organic decorations with alternating triangular and curved pediments typical of Neapolitan Baroque design. These details reflect how local architects expressed their style through stone and carved ornaments on palace facades.

The palace is a private residence divided into apartments since 1909, so the interior, courtyard and stairway are not open to visitors. The main facade facing the Palazzo degli Studi was restored in 2025 and can be viewed from the street on the San Potito hill. Look up at the portal and windows from outside.

Above the portal's round arch sits a marble coat of arms of the Cito family, complete with a marquisal crown, flanked by Ionic pilasters over rusticated pilaster strips. The portal itself derives from the 17th-century doorway of Palazzo Terralavoro.