Nkhotakota Game Reserve, Game reserve in central Malawi.

Nkhotakota Game Reserve is an 1,800-square-kilometre reserve near Lake Malawi in the Great Rift Valley, with dambos and miombo woodland of Brachystegia trees and long grasses. Its terrain falls from the 1,638 m escarpment to a plain at 500–600 m, cut by three rivers, and includes a 44-hectare patch of mid-altitude rainforest on Chipata Mountain.

The reserve came under major conservation efforts starting in 2015, which led to relocating more than 500 elephants from other parts of Malawi between 2016 and 2017. These actions significantly strengthened wildlife populations throughout the area.

The reserve's name comes from the town of Nkhotakota, whose name is often said to mean "corner-corner" in Chichewa, referring to its old role as a meeting place for caravans. The Tongole Foundation, linked to Tongole Wilderness Lodge opened in 2011, supports nearby communities and schools. Bentry Kalanga was the lodge's managing director as of 2013.

Access is via the eastern boundary near the Bua River, where the tented Bua River Lodge overlooks the river; a campsite on Chipata Mountain is used by self-navigating visitors. The reserve's 27 rangers patrol terrain that drops from the 1,638 m escarpment to the plain beside Lake Malawi. Roads and a fence enclose a sanctuary within the reserve.

Three major rivers flow through the reserve from the Great Rift Valley escarpment down to Lake Malawi, each creating its own distinct ecosystem. This network of waterways supports an unusually high number of bird species found throughout the area.