Skeleton Canyon, Canyon in the Peloncillo Mountains, New Mexico and Arizona, United States.

Skeleton Canyon is a canyon in the Peloncillo Mountains, 30 miles (50 km) northeast of Douglas, Arizona, on the Arizona–New Mexico line. It connects the Animas Valley of New Mexico with the San Simon Valley of Arizona. The flat, dry valley floor of pale brown earth holds scattered green shrubs, a pale road curving along the left side, and a pebbly wash cutting down the centre-right beneath slopes that rise to a distant ridge.

Skeleton Canyon was a main route between the United States and Mexico for legal and illegal traffic. In 1879 outlaw Cowboys attacked Mexican Rurales and stole their cattle; in July 1881 Curly Bill Brocius killed about a dozen silver smugglers, and Mexican forces retaliated by killing Newman Haynes Clanton and others driving cattle through Guadalupe Canyon. Geronimo surrendered to General Nelson A. Miles at the canyon's western edge on September 4, 1886.

Mexican herders and travellers knew the canyon as Cañon Bonita, and the present name comes from the cattle bones and human remains left along the route by drives from Mexico. The surrender of Geronimo to General Nelson A. Miles on September 4, 1886, took place at the canyon's western edge, on land that is now private; a commemorative monument stands northwest along SR 80 at its junction with Skeleton Canyon Road.

Visiting requires caution due to rough ground, sharp rocks, and thorny desert plants throughout the area. Sturdy footwear and attentive observation of your surroundings are strongly recommended.

Before it was called Skeleton Canyon, the route was known as Guadalupe Canyon; the present name came from the bones of cattle and humans left behind by cattle drives from Mexico. The canyon also carried the Mexican name Cañon Bonita.