Serranía de la Macarena, Mountain range in Meta department, Colombia

Serranía de la Macarena is an isolated range in Meta department, Colombia, running north to south for about 120 km and 30 km wide, separated from the East Andes by some 40 km at its northern end. Its highest point, El Gobernador, reaches 2,615 m, the highest in the Orinoquía region. The range belongs to the Guiana Shield, and its oldest Precambrian rocks have been dated at 1461±10 million years.

The Colombian government declared this area the country's first national nature reserve in 1948. It later gained national park status in 1971.

The range is named after the Virgin of Hope of Macarena, a Marian devotion brought from Spain, not after any local chapel. Near the Guayabero River, the Angosturas I and II petroglyphs are rock carvings left by ancient cultures. The area was settled from the mid-20th century by peasants displaced from the Andes.

Travelers reach the area by road from Villavicencio to San Juan de Arama or by plane to the settlement of La Macarena. Most visitor routes involve walking through dense forest and require guided hikes with local guides who know the trails and terrain.

Four different ecosystems meet here: the Andes, the Amazon basin, the Orinoco region, and the Guiana Shield. This rare overlap creates an exceptional diversity of plants and animals not found together anywhere else.