Saint Dominic Church, Colonial church in Santo Domingo, Colombia.

Saint Dominic Church is a Catholic temple in Santo Domingo, Antioquia, designed by Heliodoro Ochoa of Sonsón. Its dome rises 55 m with a diameter of 8.80 m, and its towers reach 80 m. The brick church, built under architect Luciano Jaramillo, has a galvanized iron dome painted silver.

The parish was erected in 1798, but the existing church structure had deteriorated and was demolished. Construction of the new church began in 1868 on the same site, started by Father Ramón María Zuluaga during his third term as parish priest (1867–1871). Father Ángel María Gómez, parish priest from 1878 to 1902, oversaw the brickwork of the towers, dome and roof; a bust of him stands in the atrium.

The church serves as a gathering place for the community during religious ceremonies and important celebrations throughout the year. Local families mark their major life events within these walls.

Visit outside of service times to explore the interior without interruption. The building is generally open on most days, so checking locally for specific visiting hours is recommended.

The first brick dome collapsed, so the parish priest Sabino Giraldo had plans sent to the United States and a new dome was made of galvanized iron sheet. Installed under Marco A. Botero (1907–1910), it still needs its silver paint renewed.