O'Reilly House, Historic house in St. Augustine, Florida, United States.

The O'Reilly House, officially the Father Miguel O'Reilly House Museum and also called the House of Don Lorenzo de Leon, stands at 131 Aviles Street in St. Augustine, Florida. The historic home holds exhibits on the Catholic heritage of St. Augustine and was added to the U.S. National Register of Historic Places on October 15, 1974.

The house is also known as the House of Don Lorenzo de Leon and now serves as the Father Miguel O'Reilly House Museum. It was listed on the U.S. National Register of Historic Places on October 15, 1974. The Historic American Buildings Survey documented it as No. FL-123, with 8 photos, 3 measured drawings and 8 data pages.

The house displays Spanish colonial design elements still visible in its structure and furnishings today. The rooms tell the story of how wealthy families in St. Augustine lived and used their homes as gathering spaces.

The building sits in the historic downtown area that can be explored on foot with parking available nearby. The area is well served by sidewalks, though visitors should expect older stairs and uneven floors inside the structure.

The Historic American Buildings Survey documented the house as No. FL-123, recording 8 photos, 3 measured drawings and 8 data pages; its address appears there as 32 Aviles Street, while the city lists it at 131 Aviles Street. The building is also listed by Florida's Office of Cultural and Historical Programs among St. Johns County sites.