Museum of Science & History, Science and children's museum in Jacksonville, United States.

The Museum of Science & History (MOSH) occupied a city-owned building on the Southbank Riverwalk, with 82,200 square feet over three floors of permanent and traveling exhibits. Its core displays included Atlantic TAILS: Coastal Creatures of Northeast Florida, the Florida Naturalist's Center, Health in Motion, JEA PowerPlay, Currents of Time: A History of Jacksonville & Northeast Florida, and the Bryan-Gooding Planetarium. The Southbank building closed on September 1, 2025.

The Jacksonville Children's Museum was chartered in 1941 and first occupied a Victorian mansion in Riverside. Construction on the city-owned Southbank site began in 1965 and the building opened in 1969. It became the Jacksonville Museum of Arts and Sciences in 1977, was accredited by the American Alliance of Museums in 1983, and took the name Museum of Science and History in 1988, when 37,500 square feet including the planetarium were added. A 1994 renovation brought it to 82,200 square feet; the Southbank building closed on September 1, 2025, ahead of a move to the Northbank.

The core exhibit Currents of Time traces Jacksonville and the First Coast from the pre-Columbian era to the 1950s. A historic mural by Elmer Grey, Interpreting Northeast Florida, is displayed in the museum. The Florida Naturalist's Center keeps native amphibians, reptiles and birds of Northeast Florida.

The museum stood on the Southbank Riverwalk at 1025 Museum Circle, on the downtown side of the St. Johns River. Its Southbank building closed on September 1, 2025, and the city-owned structure was slated for demolition, so check the current site before travelling. Members were directed to NARM- or ASTC-affiliated museums instead.

The Bryan-Gooding Planetarium, renamed in 2010 after a projector and sound upgrade, holds one of the largest single-lens planetariums in the United States. It sits in the wing added in 1988, when the museum took its present name.