Hôtel de région des Hauts-de-France, Regional government building in Euralille district, Lille, France.

The Hôtel de région des Hauts-de-France stands at 151 avenue du Président-Hoover in Lille, on the site of the former Grand Palais of the city's trade fair. Its 67-metre "Signal" tower pairs a narrow band of grey grooved panels with a curved green-tinted glass curtain wall, while the 12-metre "Nappe" below holds the committee rooms, the plenary chamber and offices. Road traffic passes beneath the building.

The Hôtel de région was built on the site of the Lille trade fair buildings, including the Grand Palais hall, destroyed in 1993. In 1999 Michel Delebarre grouped the regional services scattered across 12 rented sites, and the architectural competition was won by Luc Delemazure with Gilles Neveux, Francis Leviel and the Wilmotte firm. Construction in two phases uncovered Vauban fortification foundations and required defusing a wartime bomb. Since 1 January 2016 it has housed the Hauts-de-France regional council, after serving Nord-Pas-de-Calais.

The building has housed the Hauts-de-France regional council since 1 January 2016; before that it was the seat of the Nord-Pas-de-Calais council. Its name and the white "Hauts-de-France" sign on the grey facade mark the merger of Nord-Pas-de-Calais and Picardy into one region. The architects were Luc Delemazure with Gilles Neveux, Francis Leviel and the Wilmotte firm for interiors.

The building stands at 151 avenue du Président-Hoover, reached by Lille Grand Palais metro station; road traffic passes beneath the structure. The site was bought from the SEM Euralille. As the seat of the regional council, it is a working administrative building rather than a visitor site.

The building was deliberately divided into two visual parts: a wider lower section and a narrower upper tower, creating an uncommon design for an administrative building. This split design allowed for more efficient space planning and separate functional zones for different departments.