Ex Istituto farmaceutico Serono, Research facility in Prenestino-Labicano district, Rome, Italy

The Ex Istituto farmaceutico Serono is a large building on the corner of via Casilina and piazza del Pigneto, near Ponte Casilino. Designed by architect Antonio Flory, it opened on 22 March 1909 as Rome's first chemical-pharmaceutical plant. It shows imposing facades on both streets and is clearly visible from the Ponte Casilino railway bridge.

The institute was founded in 1909 and was one of Rome's first centers for pharmacy and chemistry, operating until 1977. During its lifetime, it experienced various changes, including damage during World War II.

The building is named after Cesare Serono, the Turin entrepreneur and professor who founded the national medico-pharmacological institute in Turin on 10 March 1906 and opened this Rome plant in 1909. Serono, aided by Prince Prospero Colonna, later headed the Union of Industrialists of Lazio and sat in the Chamber of Deputies in the 28th and 29th legislatures of the Kingdom of Italy.

The building is visible from Piazza del Pigneto and Via Casilina and is easy to reach from both streets. Today it has been converted into a hotel, so visitors can view it from outside or make use of the current facility.

The building was designed by the architect Antonio Flory and inaugurated on 22 March 1909 in the presence of the city authorities and its founder, the Turin entrepreneur Cesare Serono. Serono, later a deputy in the XXVIII and XXIX legislatures of the Kingdom of Italy, expanded the factory in the 1920s with the backing of prince and senator Prospero Colonna.