Prospect Creek, human settlement in Yukon–Koyukuk Census Area, Alaska, United States of America

Prospect Creek is a settlement in the Yukon-Koyukuk Census Area of northern Alaska, about 180 miles north of Fairbanks and just above the Arctic Circle. What remains is a large gravel pad, the small Prospect Creek Airport airstrip and Pump Station 5 (Jim River Station) of the Trans-Alaska Pipeline System. The flat site is surrounded by boreal forest and undulating terrain.

The area attracted gold prospectors around 1900 who searched for minerals using simple tools, though no permanent settlements developed. In the 1970s, the site saw its peak activity when a major worker camp housing up to 1500 people was established to support Trans-Alaska Pipeline System construction.

The site is accessible only by the gravel Dalton Highway or small planes, making a visit require careful planning. Visitors must prepare for extreme cold, snow cover during winter, and potential wildlife encounters such as bears or moose.

Prospect Creek recorded −79.8 °F (−62.1 °C) on January 23, 1971, the lowest temperature ever officially measured in the United States. The reading came from a weather station run between 1970 and 1980 for the Trans-Alaska Pipeline construction; observations resumed in 2015. The same day the maximum stayed at −64 °F (−53 °C).