Rufus M. Rose House, Queen Anne style house in the SoNo district, Atlanta, United States

The Rufus M. Rose House is a late Victorian Queen Anne style house on a narrow lot on Peachtree Street in Atlanta's SoNo district. Its red-brick exterior has bayed and multi-gabled facades with windows of many shapes and sizes, and carved marble steps once led from the sidewalk to the front porch. The original slate roof and front porch are gone.

Built in 1901 by architect Emil Charles Seiz, this residence belonged to Dr. Rufus Rose, a Civil War-era physician who founded a distillery business. The building emerged during a period when Atlanta's prosperous residents expressed their wealth through elaborate construction.

The house is the last surviving piece of Peachtree Street's residential era; its small yard is described as the "singular survivor from Peachtree's residential heyday." It was built for Dr. Rufus Mathewson Rose, a former druggist and Civil War doctor who moved to Atlanta in 1867 and founded the R. M. Rose Co. Distillery in Vinings.

The house stands on a narrow lot on Peachtree Street, one and a half blocks south of North Avenue in the SoNo district. It has been vacant since 2001 and is listed as endangered, so it is seen from the sidewalk rather than visited inside. Renovations began in September 2021 and no future plans have been announced.

James H. Elliot Sr. bought the house in 1945 and ran J.H. Elliot's Antiques and the Atlanta Museum there until 1998. Its collection included furniture belonging to Margaret Mitchell, personal items of Bobby Jones, Emperor Haile Selassie's throne and a Japanese Zero war plane.