Santa Lucia in Septisolio, Cardinal title at Palatine Hill, Rome, Italy

Santa Lucia in Septisolio was an ancient Roman church with a diaconia, standing at the southern corner of the Palatine Hill beside the Septizodium of Septimius Severus. Armellini described it as assai vasta e ricchissimamente decorata, quite vast and most richly decorated. Hülsen placed it closer to the Torre della Moletta in the Circus Maximus.

Santa Lucia in Septisolio is listed in the Liber Pontificalis among Rome's oldest deaconries, mentioned in the biographies of Leo III (795–816) and Gregory IV (827–844). Its cardinal title was suppressed in 1587 under Sixtus V, and the church is generally held to have been demolished in his pontificate (1585–1590), though Hülsen argued it had already fallen into ruins when the title lapsed.

The church served as a stopping point where pilgrims gathered during their journeys through Rome and participated in liturgical celebrations. It formed part of the sacred circuit that shaped medieval Rome's spiritual geography.

The site is located on the Palatine Hill and survives today only through historical documents, as the physical structure no longer exists. Visitors interested in ancient Roman and medieval sites can explore the Palatine grounds to understand the location where the church once stood.

The catalogue of Pietro Mallio, compiled under Pope Alexander III (1159–1181), records the church as S. Lucie Palatii in cyrco iuxta Septa Solis, placing it on the Palatine beside the Circus Maximus. Mariano Armellini read the many variants of the name as corruptions of one monument's title, while Hülsen argued the church stood nearer the Torre della Moletta than the Septizodium ruins.