Sanctuary of the Madonna del Silenzio, Gothic Revival shrine in Avezzano, Italy.

The Sanctuary of the Madonna del Silenzio is a single-nave church in the Frati district of Avezzano, built between 1920 and 1922. Its essential, simple lines frame a niche above the altar holding the icon of the Virgin of Silence. The mural paintings are by Francesco Antonio Bianchi.

The Capuchin friars of Abruzzo acquired land near Monte Salviano and began building the convent and church in 1917, funded by citizens' donations and a contribution from Pope Benedict XV. The complex was consecrated and opened for worship between 1 May 1920 and 30 April 1922, initially dedicated to the Sacred Heart. In 1971 Bishop Domenico Valerii elevated the church to a parish and dedicated it to Saint Francis of Assisi. On 13 May 2020 Bishop Pietro Santoro raised it to a diocesan sanctuary with the title Madonna del Silenzio in San Francesco.

The icon of the Vergine del Silenzio was commissioned in 2010 by Father Emiliano Antenucci and made at the Mater Ecclesiae abbey on San Giulio island, Lake Orta; it draws on an 8th-century Coptic painting of Saint Anne. A copy was blessed by Pope Francis on 18 May 2015 and placed at the main entrance of the Apostolic Palace at the San Damaso courtyard; the original was blessed by him on 15 June 2016.

The sanctuary is typically open during morning and late afternoon hours, allowing visitors time for private prayer. It helps to wear comfortable shoes and check visiting times in advance before planning your visit.

The venerated image is a panel cut from a larger altarpiece, once kept at Santa Maria in Vico and destroyed with that church in the 1915 Marsica earthquake. The damaged altarpiece went to Rome's Palazzo Venezia museum, then Velletri; the panel returned to Avezzano in 1973.