First National Bank of Commerce Building, Residential and commercial tower in Central Business District, New Orleans, United States.

The First National Bank of Commerce Building is a 19-story, 252-foot (77 m) tower at 210 Baronne Street in New Orleans' Central Business District, designed by Emile Weil in the Neoclassical style and completed in 1927. It now operates as The Four Winds, a combination commercial and luxury apartment building developed by Kailas Companies, and ranks as the city's 34th-tallest building.

The building was designed by architect Emile Weil in 1927 and originally served as headquarters for Canal Bank and Trust before becoming the First National Bank of Commerce office. It documents the banking sector's expansion in New Orleans during the pre-war period.

The building's name changed with its occupants: opened in 1927 for Canal Bank and Trust, it carried the First National Bank of Commerce name for almost 90 years until that bank collapsed in 2017. It now operates as The Four Winds, a combination commercial and luxury apartment building developed by Kailas Companies.

The building stands at 210 Baronne Street, in the Central Business District, and is now the Four Winds, a combination commercial and luxury apartment building, so the lobby and upper floors are not open to the public. Visitors see the restored 1927 facade from the street; the 19 floors rise 252 feet (77 m).

After a major 2015 restoration, the original bank building was converted into luxury apartments called Four Winds, a rare adaptive reuse for a historic structure in this area. The transformation preserves the historic facade while the interior meets modern residential standards.