St. James AME Church, Gothic Revival church in New Orleans, United States.

St. James AME Church is a Neo-Gothic building at 222 N. Roman Street in New Orleans, constructed in 1848. Its design shows pointed arches and vertical emphasis typical of the Gothic Revival style. The church was listed on the National Register of Historic Places in 1982.

The congregation was established in 1844 as the first African Methodist Episcopal church in the Deep South region. The building itself was constructed in 1848 by architects Diboll & Owen and gained recognition on the National Register in 1982.

The name St. James AME marks its affiliation with the African Methodist Episcopal Church, the oldest predominantly African American denomination in the United States. Founded in 1844, it was the first church of African Methodism established in the Deep South. The Reverend Dr. Demetrese Phillips serves as pastor.

The church is located on N. Roman Street in downtown New Orleans and is easy to find in the area. Visitors should keep in mind this is an active place of worship, so appropriate behavior and possibly contacting ahead is recommended.

The church appears in the 2012 film 21 Jump Street, which borrowed its title from the congregation's name. The movie used the building as the setting for the namesake high school, so the historic Roman Street church stands in for a fictional school on screen.