101 Second Street, Office skyscraper in South of Market, San Francisco, United States

101 Second Street is a 26-story office tower in the South of Market district, on Mission Street, completed in 2000 to a design by Skidmore, Owings and Merrill. Its angled corner sets pale grey stone panels with small square windows beside a green-blue glass curtain wall, with a vertical stack of projecting bay windows running down the edge. A four-story glass-clad atrium at street level serves as public space.

101 Second Street was developed by a partnership of Cousins Properties and Myers Development Company alongside 55 Second Street, and completed in 2000. The site was first planned in the early 1990s as a pointed tower of over 40 stories for a Canadian developer, a design by Skidmore, Owings and Merrill that won a city-run competition; the office recession stalled it, and Steve O'Brien redesigned it around 1994. Hines bought the building in September 2004 for US$144 million and sold it to Invesco Real Estate in January 2014 for about $297 million.

The four-story glass atrium at street level is a public space, and on warm days the building opens at ground level. Its art pavilion has shown commissions by painter Charles Arnoldi and sculptor Larry Bell. The tower stands in the South of Market district on Mission Street.

The tower stands on Mission Street in the South of Market district, not in the Financial District. Its glass-clad four-story atrium works as a public space, and on warm days the street level is opened up. The building sits near the Second Street and Mission Street corner, a short walk from Market Street transit.

The site sat idle after a 1990s office recession stalled an earlier scheme: a Canadian developer's "point tower" of over 40 stories, chosen in a City building department design competition. Redesigned around 1994 by Skidmore, Owings & Merrill's Steve O'Brien, the built tower keeps his massing, including the public atrium and the descent to Second Street.