Motsetsi, Paleontological excavation site in Gauteng, South Africa.

Motsetsi is a series of breccia-filled dolomitic caves formed in a fissure along a geological fault, about 14 km east of Sterkfontein and Kromdraai. The cave fill is dated to 1.0–1.6 million years ago from the animals recovered there.

Lee Berger discovered the site in 1999. Since then, teams from the University of the Witwatersrand and University of Zurich have conducted research excavations.

Motsetsi is a South African National Heritage Site. Its name is also written Motsetse, and the cave lies in the dolomitic rock of Gauteng, about 14 km east of Sterkfontein and Kromdraai. Excavation has been part-time, so most of the breccia infill is still untouched.

Motsetsi lies about 14 km east of Sterkfontein and Kromdraai and roughly 45 km north-northwest of Johannesburg, in Gauteng. The breccia-filled cave sits in a fissure along a geological fault, and only a very small part of the deposit has been excavated, so there is no visitor infrastructure. Access is for research teams from the University of the Witwatersrand.

Among the thousands of fossils recovered since 1999 are very well preserved remains of Dinofelis, a false saber-toothed cat. No hominid fossils have been found, and only a very small part of the site has been excavated.